Transgenic mice expressing human alpha-synuclein in noradrenergic neurons develop locus coeruleus pathology and non-motor features of Parkinson's disease
Laura M. Butkovich, Madelyn C. Houser, Termpanit Chalermpalanupap, Kirsten A. Porter‐Stransky, Alexa F. Iannitelli, Jake Sondag Boles, Grace M. Lloyd, Alexandra S. Coomes, Lori N. Eidson, Maria Elizabeth de Sousa Rodrigues, Danielle L. Oliver, Sean D. Kelly, Jianjun Chang, Nora Bengoa‐Vergniory, Richard Wade‐Martins, , Malú G. Tansey
This study develops a transgenic mouse model expressing human alpha-synuclein in noradrenergic neurons, revealing LC pathology and non-motor PD features.
Journal of Neuroscience · Aug 31, 2020Peer-reviewedNeuroscience