Jake Sondag Boles

The paper compares gut microbiomes of Parkinson's disease and inflammatory bowel disease patients, finding shared depletions in butyrate-producing bacteria across multiple datasets.

This study shows that LC injury modifies neuroinflammation in the ventral midbrain during DSS-induced colitis, highlighting the neuroprotective role of the locus coeruleus.

This study examines the gut-brain axis in a mouse colitis model, identifying immune activation, oxidative stress, and myelination disruptions in the brain linked to intestinal permeability.

The paper evaluates cell isolation methods for mouse brain immune profiling and uses PIPseq to study microglia-peripheral immune crosstalk during LPS-induced neuroinflammation.

This study develops a transgenic mouse model expressing human alpha-synuclein in noradrenergic neurons, revealing LC pathology and non-motor PD features.