Author

Alexa F. Iannitelli

Emory University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Neuroscience· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 5 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:statistical model· 1

Frequent Co-Authors

David WeinshenkeriD· 5 shared Daniel J. LustbergiD· 3 shared Larry Cameron Liles· 3 shared Anu KorukondaiD· 2 shared Arielle Segal· 2 shared Bernard MulveyiD· 2 shared Joseph D. DoughertyiD· 2 shared Katharine E McCanniD· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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5 shared papersNeuroscience

David WeinshenkerORCID

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5 papers

Recent·Most cited

Tyrosinase-induced neuromelanin accumulation triggers rapid dysregulation and degeneration of the mouse locus coeruleus

Leslie Hassanein, Bernard Mulvey, Harris E. Blankenship, Margaret Tish, Anu Korukonda, L. Cameron Liles, Amanda Lea Sharpe, Jean‐François Paré, Rosa M. Villalba, Xiangchuan Chen, Khan Hekmatyar, Jenny J. Yang, Daniel E. Huddleston, Seong Kang, Arielle Segal, , Alexa F. Iannitelli

This study shows that tyrosinase-induced neuromelanin accumulation in mouse locus coeruleus neurons causes hyperactivity, transcriptional changes, and degeneration, mimicking early stages of Alzheimer's and Parkinson's disease.

bioRxiv · Mar 7, 2023 · PreprintNeuroscience

The Neurotoxin DSP-4 Dysregulates the Locus Coeruleus-Norepinephrine System and Recapitulates Molecular and Behavioral Aspects of Prodromal Neurodegenerative Disease

Alexa F. Iannitelli, Michael A. Kelberman, Daniel J. Lustberg, Anu Korukonda, Katharine E McCann, Bernard Mulvey, Arielle Segal, Larry Cameron Liles, Steven A. Sloan, Joseph D. Dougherty, David Weinshenker

This study uses DSP-4 to model early LC-NE system changes in AD and PD, showing axon damage, neuroinflammation, and behavioral changes without LC cell death.

eNeuro · Dec 9, 2022Peer-reviewedNeuroscience

Norepinephrine and dopamine contribute to distinct repetitive behaviors induced by novel odorant stress in male and female mice

Daniel J. Lustberg, Joyce Q. Liu, Alexa F. Iannitelli, Samantha O. Vanderhoof, Larry Cameron Liles, Katharine E McCann, David Weinshenker

The paper investigates how norepinephrine and dopamine influence distinct repetitive behaviors in mice exposed to novel odorants, showing differential effects on digging and grooming.

Hormones and Behavior · Aug 1, 2022Peer-reviewedNeuroscience

Transgenic mice expressing human alpha-synuclein in noradrenergic neurons develop locus coeruleus pathology and non-motor features of Parkinson's disease

Laura M. Butkovich, Madelyn C. Houser, Termpanit Chalermpalanupap, Kirsten A. Porter‐Stransky, Alexa F. Iannitelli, Jake Sondag Boles, Grace M. Lloyd, Alexandra S. Coomes, Lori N. Eidson, Maria Elizabeth de Sousa Rodrigues, Danielle L. Oliver, Sean D. Kelly, Jianjun Chang, Nora Bengoa‐Vergniory, Richard Wade‐Martins, , Malú G. Tansey

This study develops a transgenic mouse model expressing human alpha-synuclein in noradrenergic neurons, revealing LC pathology and non-motor PD features.

Journal of Neuroscience · Aug 31, 2020Peer-reviewedNeuroscience

Central norepinephrine transmission is required for stress-induced repetitive behavior in two rodent models of obsessive-compulsive disorder

Daniel J. Lustberg, Alexa F. Iannitelli, Rachel P. Tillage, Molly Pruitt, Larry Cameron Liles, David Weinshenker

The paper investigates the role of norepinephrine in stress-induced repetitive behaviors in OCD models, finding that NE deficiency reduces compulsive behaviors and that restoring NE rescues these behaviors.

Psychopharmacology · Apr 20, 2020Peer-reviewedNeuroscience