cGAS-STING induced IFN-β acts as a dual regulator of osteoclastogenesis via direct and osteoblast-mediated mechanisms
Hannah F Simonis, Sanya Middha, Loris Graf, Ramin Naibi, Vivian Polenz, Katharina F. Kubatzky, Elisabeth Seebach
This study shows cGAS-STING-IFN-β signaling regulates osteoclastogenesis both directly in macrophages and indirectly through osteoblasts by altering the OPG-RANKL axis.
bioRxiv · May 13, 2026 · PreprintImmunology