ImmunologybioRxivPreprint
cGAS-STING induced IFN-β acts as a dual regulator of osteoclastogenesis via direct and osteoblast-mediated mechanisms
Hannah F Simonis, Sanya Middha, Loris Graf…·Elisabeth Seebach
This study shows cGAS-STING-IFN-β signaling regulates osteoclastogenesis both directly in macrophages and indirectly through osteoblasts by altering the OPG-RANKL axis.
DOI 10.64898/2026.05.09.724040