Mitochondrial Dysfunction in Endothelial Cells Drives Greater Vascular Impairment in Females with Diabetes-Associated Peripheral Artery Disease
Siân Peta Cartland, Elaina Kelland, Natalie Le, Jaideep K. Singh, Madeleine Murphy, Rafaela Campos de Menezes, Jacqueline Ku, Lorna Beattie, Lisa Turner, Jacky Loa, Lauren M. Boccanfuso, Lauren Sandeman, Millie Jiang, Polina E. Nedoboy, Malathi S.I. Dona, , Mary Meltem Kavurma
This study identifies sex-specific mitochondrial dysfunction in endothelial cells of diabetic PAD patients, showing that MitoQ improves vascular function in females.
bioRxiv · Sep 22, 2025 · PreprintPathology