Machine Learning and Directed Evolution of Base Editing Enzymes
Ramiro M. Perrotta, Svenja Vinke, Raphaël Ferreira, Michaël Moret, Ahmed Mahas, Anush Chiappino-Pepe, Lisa Maria Riedmayr, Anna-Thérèse Mehra, Louisa S. Lehmann, George McDonald Church
This work designs precise base editors with reduced bystander editing using guide RNA libraries and protein language models, improving safety and targeting efficiency.
bioRxiv · May 17, 2024 · PreprintSynthetic Biology