Raphaël Ferreira

This paper introduces SONAR, a platform for detecting nucleic acids and triggering gene expression in human cells, demonstrating its ability to sense DNA and RNA and express various protein payloads.

This paper introduces a method using single-stranded DNA templates and bacteriophage RNA polymerases to produce functional RNAs in mammalian cells, demonstrating applications in CRISPR-based genome editing.

This study shows that single nutrients do not determine breast cancer metastasis sites, and identifies purine synthesis as a key factor across multiple tissues.

This paper develops a CRISPR-based method to generate large-scale structural genomic rearrangements in human cells, revealing selection pressures and gene expression impacts of these changes.

This work designs precise base editors with reduced bystander editing using guide RNA libraries and protein language models, improving safety and targeting efficiency.

This paper develops dead-Cas9 base editors that enable large-scale genome editing in human cells by reducing DNA nicking, allowing editing of over 10,000 loci.

The paper develops CRISPR-based biocontainment circuits using transposable elements to induce cell death and create kill-switches for controlling cell lines.