Cell-to-cell signalling mediated via CO2: activity dependent axonal CO2 production opens Cx32 in the Schwann cell paranode.
Jack Butler, Lowell Mott, Amol Bhandare, Angus M. Brown, Nicholas Dale
The paper shows that CO2 produced in axons gates Cx32 hemichannels in Schwann cells, mediating neuron-to-glia signaling and affecting myelin conduction.
bioRxiv · Apr 4, 2025 · PreprintNeuroscience