Amol Bhandare

CO2-sensitive Cx26 hemichannels in dorsal raphe-ventral tegmental area pathway mediate hypercapnic arousal

This study identifies Cx26 hemichannels as a CO2 sensor in serotonergic neurons that mediates hypercapnic arousal by enabling serotonin release.

Cell-to-cell signalling mediated via CO2: activity dependent axonal CO2 production opens Cx32 in the Schwann cell paranode.

The paper shows that CO2 produced in axons gates Cx32 hemichannels in Schwann cells, mediating neuron-to-glia signaling and affecting myelin conduction.

Neural correlate of reduced respiratory chemosensitivity during chronic epilepsy

This study investigates changes in respiratory chemosensitivity in mice with chronic epilepsy, finding reduced adaptive responses to hypercapnia and shifts in neuronal response patterns over time.

Analyzing the neuroglial brainstem circuits for respiratory chemosensitivity in freely moving mice

The paper uses imaging to study neural activity in brainstem regions during CO2 exposure in mice, revealing distinct roles for RTN, Raphe, and pFL in respiratory chemosensitivity.

Connexin26 mediates CO2-dependent regulation of breathing via glial cells of the medulla oblongata

The paper shows that CO2-binding to Cx26 in glial cells of the medulla oblongata contributes significantly to ventilatory responses to CO2.