Jack Butler

The paper identifies connexins, aquaporins, and carbonic anhydrase 2 as essential components for cellular CO2 sensing, demonstrating their combined necessity through experimental and simulation studies.

This study identifies connexins in invertebrate genomes, showing their evolutionary origin predates chordates and functional similarity to vertebrate connexins in innate immunity.

The paper demonstrates that Cx43 hemichannels open in response to CO2, resolving a discrepancy between in vivo and in vitro studies.

The paper identifies and optimizes bicyclic peptide inhibitors of Staphylococcus aureus α-hemolysin, achieving sub-micromolar affinity and demonstrating functional inhibition of toxin activity.

This study investigates permselectivity of connexin hemichannels for small molecules, finding that selectivity varies among connexins and is influenced by factors beyond molecular size.

This study identifies Cx26 hemichannels as a CO2 sensor in serotonergic neurons that mediates hypercapnic arousal by enabling serotonin release.

The paper shows that CO2 produced in axons gates Cx32 hemichannels in Schwann cells, mediating neuron-to-glia signaling and affecting myelin conduction.