A human gut-BBB-brain microphysiological model for studying neurodegenerative diseases
Yu-Shan Deng, Wanpeng Wang, Fei Wang, Guoming Ma, Jianfeng Lin, Chenxi Yan, Yiling Zhou, Lu-Yao Wang, Xue-Qi Gong, Li Sun, Jian Zhao, Gang Pei, Lin Zhang, Wenyuan Wang
This paper develops a human gut-BBB-brain microphysiological model to study neurodegenerative diseases and finds that gut-brain interactions can promote brain organoid maturation and recapitulate AD pathology.
Lab on a Chip · Jan 1, 2026Peer-reviewedNeuroscience