Wenyuan Wang

This paper develops a human gut-BBB-brain microphysiological model to study neurodegenerative diseases and finds that gut-brain interactions can promote brain organoid maturation and recapitulate AD pathology.

This study uses intramuscular AAV therapy to silence SOD1 in neonatal mice, delaying ALS onset and improving survival and motor function.

This study develops an age-prediction model using DNA methylation from a single ELOV2 genomic region, validated across cohorts and forensic applications.

The paper develops a secretome profiling method for astrocytes and identifies proteins involved in disease-related toxicity and neuroprotection.

This study profiles temporal RNA-seq in iPSC-derived motor neurons from ALS patients with specific mutations, identifying shared gene expression and splicing defects across different mutations.

This study identifies id2b as a gene regulated by biomechanical forces in zebrafish hearts, showing its role in both myocardial contractility and valve formation through interactions with tcf3b and nrg1.

This study corrects a mutation in achondroplasia patient-derived iPSCs using CRISPR-Cas9 and restores their chondrogenic differentiation ability.