Author

Jianfeng Lin

Yale UniversityORCID 0000-0001-5732-1209Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:cryo-EM· 1 Approach:mechanistic / dynamical model· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Yong XiongiD· 2 shared Amanda C. MackeiD· 1 shared Chenghao ZhuiD· 1 shared Chenxi YaniD· 1 shared Christian FreniereiD· 1 shared Christopher AikeniD· 1 shared Chunxiang WuiD· 1 shared Elizabeth BaileyiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersBiochemistry

Yong XiongORCID

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3 papers

Recent·Most cited

BiochemistrybioRxivPreprintJan 11, 2026

A Hybrid Gag Lattice as a Structural Intermediate in HIV-1 Maturation

Megan E. Meuser, Chunxiang Wu, Amanda C. Macke…·Yong Xiong

This study identifies a hybrid Gag lattice as an intermediate in HIV-1 maturation, showing it is stabilized by IP6 and essential for infectivity.

2 citations

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NeuroscienceLab on a ChipPeer-reviewedJan 1, 2026

A human gut-BBB-brain microphysiological model for studying neurodegenerative diseases

Yu-Shan Deng, Wanpeng Wang, Fei Wang…·Wenyuan Wang

This paper develops a human gut-BBB-brain microphysiological model to study neurodegenerative diseases and finds that gut-brain interactions can promote brain organoid maturation and recapitulate AD pathology.

DOI 10.1039/d6lc00630b

humanexperimental assay

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Molecular BiologyNature CommunicationsPeer-reviewedNov 28, 2025

Visualizing the translation landscape in human cells at high resolution

Wei Hui Zheng, Yuekang Zhang, Jimin Wang…·Yong Xiong

The paper uses in situ cryo-EM to visualize human ribosome structures and functional states, revealing new protein interactions and polysome interfaces.

32 citationstop 1%

humanprotein structure

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