Guoming Ma

This paper develops a human gut-BBB-brain microphysiological model to study neurodegenerative diseases and finds that gut-brain interactions can promote brain organoid maturation and recapitulate AD pathology.

The paper develops a secretome profiling method for astrocytes and identifies proteins involved in disease-related toxicity and neuroprotection.

This study profiles temporal RNA-seq in iPSC-derived motor neurons from ALS patients with specific mutations, identifying shared gene expression and splicing defects across different mutations.