Developmental BiologybioRxivPreprint
A developmentally programmed splicing failure attenuates the DNA damage response during mammalian zygotic genome activation
Christopher D. R. Wyatt, Bárbara Pernaute, André Gohr…·Manuel Irimia
The paper shows that during zygotic genome activation, embryos exhibit temporary splicing failures in DNA damage response genes, regulated by Snrpb and Snrpd2, which reduce DNA damage response.