Bárbara Pernaute

The paper compares gene regulatory networks in mouse and pig limb development to reveal conserved and divergent regulatory programs and mechanisms of developmental robustness.

The paper identifies mitochondrial defects in eliminated cells during early mouse development and shows that cell competition removes cells with mitochondrial DNA mutations and sequence changes.

The paper shows that during zygotic genome activation, embryos exhibit temporary splicing failures in DNA damage response genes, regulated by Snrpb and Snrpd2, which reduce DNA damage response.

This study identifies DRP1-mediated mitochondrial dynamics as a regulator of apoptotic response during embryonic differentiation in mouse cells.