André Gohr

Insplico: Effective computational tool for studying intron splicing order genome-wide with short and long RNA-seq reads

Insplico quantifies intron splicing order using short and long RNA-seq reads, revealing conserved patterns and novel features across species and tissues.

A developmentally programmed splicing failure attenuates the DNA damage response during mammalian zygotic genome activation

The paper shows that during zygotic genome activation, embryos exhibit temporary splicing failures in DNA damage response genes, regulated by Snrpb and Snrpd2, which reduce DNA damage response.

RES complex is associated with intron definition and required for zebrafish early embryogenesis

The study shows the RES complex is essential for zebrafish early development and intron splicing, with specific intronic features associated with its activity.