Loss of CLN3 in microglia leads to impaired lipid metabolism and myelin turnover
Seda Yaşa, Elisabeth S. Butz, Alessio Vittorio Colombo, Uma Chandrachud, Luca Montore, Sarah K. Tschirner, Matthias Prestel, Steven D. Sheridan, Stephan A. Müller, Janos Groh, Stefan F. Lichtenthaler, Sabina Tahirović, Susan L. Cotman
This study shows that loss of CLN3 in microglia causes lipid metabolism defects and impaired myelin turnover, leading to early neuroinflammation in a mouse model of CLN3 disease.
Communications Biology · Oct 22, 2024Peer-reviewedNeuroscience