Stress-driven emergence of heritable non-genetic drug resistance
Jinglin Lucy Xie, Sifei Yin, Theodore S. Yang, Kiran A. Chandrasekher, Luke Hanson, Sang Hu Kim, Lucas Esqueda, Catherine Anne Hogan, Niaz Banaei, June L. Round, Kyla S. Ost, Judith G. Berman, Daniel F. Jarosz
The paper identifies a non-genetic, heritable mechanism of drug resistance in Candida albicans triggered by subtherapeutic fluconazole exposure, which can be reversed and involves prion-like epigenetic processes.
bioRxiv · Dec 20, 2024 · PreprintMicrobiology