LC3C-ATG4D regulatory axis supports coronavirus replication organelle formation independently of canonical autophagy
Štěpánka Vlachová, Lucia Iovine, Valentina Marano, Elena Polishchuk, Michele Cillo, Lorena Donnici, Pedro Machado, Paolo Swuec, Carmine Settembre, Paolo Grumati, Raffaele De Francesco, Lina Herhaus, Mirko Cortese
This study identifies a non-canonical role for the LC3C-ATG4D axis in supporting coronavirus replication organelle formation, independent of canonical autophagy.
bioRxiv · Aug 11, 2026 · PreprintCell Biology