Genetic mapping of lifespan and mitochondrial stress response in C. elegans
Xiaoxu Li, Weisha Li, Arwen W. Gao, Yunyun Zhu, Elena Katsyuba, Katherine A. Overmyer, Terytty Yang Li, Ziwen Wang, Luc Legon, Lucie Plantade, Laurent Mouchiroud, Matteo Cornaglia, Hao Li, Riekelt H. Houtkooper, Joshua J. Coon, Johan H. Auwerx
The paper identifies a UPRmt modulator, fipp-1/FIP1L1, that extends lifespan in C. elegans and is associated with metabolic homeostasis in humans.
bioRxiv · Jun 26, 2025 · PreprintGenetics