Author

Xiaoxu Li

École Polytechnique Fédérale de LausanneORCID 0000-0001-5121-9190Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2 Systems Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 4 Approach:statistical model· 4 Assay:bulk RNA-seq· 3 Organism:C. elegans· 2 Organism:mouse· 2 Approach:benchmark study· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Johan H. AuwerxiD· 4 shared Arwen W. GaoiD· 2 shared Elena KatsyubaiD· 2 shared Evan G. WilliamsiD· 2 shared Jean‐David MoreliD· 2 shared Jonathan SulciD· 2 shared Joshua J. CooniD· 2 shared Katherine A. OvermyeriD· 2 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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4 shared papersGenetics

Johan H. AuwerxORCID

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4 papers

Recent·Most cited

GeneticsNaturePeer-reviewedApr 22, 2026

Genetic Modulation of Lifespan: Dynamic Effects, Sex Differences, and Body Weight Trade-offs

Danny Arends, David George Ashbrook, Suheeta Roy…·Robert W. Williams

This study identifies genetic loci affecting lifespan dynamics, sex differences, and body weight trade-offs in mice using an actuarial approach.

3 citations

mousestatistical model

𝕏 PostBluesky

GeneticsbioRxivPreprintJun 26, 2025

Genetic mapping of lifespan and mitochondrial stress response in C. elegans

Xiaoxu Li, Weisha Li, Arwen W. Gao…·Johan H. Auwerx

The paper identifies a UPRmt modulator, fipp-1/FIP1L1, that extends lifespan in C. elegans and is associated with metabolic homeostasis in humans.

DOI 10.1101/2025.06.26.661693

C. elegansbulk RNA-seq

𝕏 PostBluesky

Systems BiologyCell ReportsPeer-reviewedOct 1, 2024

High-content phenotypic analysis of a C. elegans recombinant inbred population identifies genetic and molecular regulators of lifespan

Arwen W. Gao, Gaby El Alam, Yunyun Zhu…·Johan H. Auwerx

The paper identifies genetic and molecular regulators of lifespan in C. elegans using a recombinant inbred population and validates their relevance to human age-related diseases.

9 citations

C. elegansproteomics

𝕏 PostBluesky

Systems BiologybioRxivPreprintMar 22, 2023

Genetic and dietary modulators of the inflammatory response in the gastro-intestinal tract of the BXD mouse genetic reference population

Xiaoxu Li, Jean‐David Morel, Giorgia Benegiamo…·Johan H. Auwerx

The paper identifies genetic and dietary factors influencing intestinal inflammation in BXD mice, finding MUC4 and EPHA6 as potential mediators of IBD susceptibility.

1 citation

mousebulk RNA-seq

𝕏 PostBluesky