Author

Yunyun Zhu

University of Wisconsin–MadisonORCID 0000-0002-0087-3464Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Systems Biology· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Organism:C. elegans· 3 Research Focus:gene regulatory network inference· 3 Approach:statistical model· 3 Assay:metabolomics· 2 Assay:proteomics· 2 Research Focus:differential expression· 1 Research Focus:GWAS / association mapping· 1

Frequent Co-Authors

Arwen W. GaoiD· 3 shared Johan H. AuwerxiD· 3 shared Joshua J. CooniD· 3 shared Katherine A. OvermyeriD· 3 shared Riekelt H. HoutkooperiD· 3 shared Terytty Yang LiiD· 3 shared Amélia LalouiD· 2 shared Elena KatsyubaiD· 2 shared

Activity by Year

2022-2025 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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3 shared papersSystems Biology

Arwen W. GaoORCID

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3 papers

Recent·Most cited

Genetic mapping of lifespan and mitochondrial stress response in C. elegans

Xiaoxu Li, Weisha Li, Arwen W. Gao, Yunyun Zhu, Elena Katsyuba, Katherine A. Overmyer, Terytty Yang Li, Ziwen Wang, Luc Legon, Lucie Plantade, Laurent Mouchiroud, Matteo Cornaglia, Hao Li, Riekelt H. Houtkooper, Joshua J. Coon, Johan H. Auwerx

The paper identifies a UPRmt modulator, fipp-1/FIP1L1, that extends lifespan in C. elegans and is associated with metabolic homeostasis in humans.

bioRxiv · Jun 26, 2025 · PreprintGenetics

High-content phenotypic analysis of a C. elegans recombinant inbred population identifies genetic and molecular regulators of lifespan

Arwen W. Gao, Gaby El Alam, Yunyun Zhu, Weisha Li, Jonathan Sulc, Xiaoxu Li, Elena Katsyuba, Terytty Yang Li, Katherine A. Overmyer, Amélia Lalou, Laurent Mouchiroud, Maroun S. Bou Sleiman, Matteo Cornaglia, Jean‐David Morel, Riekelt H. Houtkooper, , Johan H. Auwerx

The paper identifies genetic and molecular regulators of lifespan in C. elegans using a recombinant inbred population and validates their relevance to human age-related diseases.

Cell Reports · Oct 1, 2024Peer-reviewedSystems Biology

Multi-omics analysis identifies essential regulators of mitochondrial stress response in two wild-type C. elegans strains

Arwen W. Gao, Gaby El Alam, Amélia Lalou, Terytty Yang Li, Marte Molenaars, Yunyun Zhu, Katherine A. Overmyer, Evgenia Shishkova, Kevin Hof, Maroun S. Bou Sleiman, Riekelt H. Houtkooper, Joshua J. Coon, Johan H. Auwerx

The paper integrates multi-omics data from two C. elegans strains to show that doxycycline-induced UPRmt affects mitochondrial function and lifespan through shared and strain-specific pathways.

iScience · Jan 5, 2022Peer-reviewedSystems Biology