Arwen W. Gao

The paper identifies a UPRmt modulator, fipp-1/FIP1L1, that extends lifespan in C. elegans and is associated with metabolic homeostasis in humans.

The paper identifies plasma triacylglycerol (TG) length and saturation levels as markers of healthy aging in humans, showing that higher physical activity is linked to shorter TG chains and more double bonds.

The paper identifies genetic and molecular regulators of lifespan in C. elegans using a recombinant inbred population and validates their relevance to human age-related diseases.

The paper integrates multi-omics data from two C. elegans strains to show that doxycycline-induced UPRmt affects mitochondrial function and lifespan through shared and strain-specific pathways.

The paper introduces GeneBridge, a method for imputing gene function and predicting module connections using multi-species expression data, and demonstrates its application across 1,700 datasets.

This study shows glycine supplementation extends C. elegans lifespan and alters gene expression, with effects dependent on the methionine cycle.

The paper identifies genetic loci controlling metabolite levels in C. elegans using recombinant inbred lines and QTL mapping.