Hao Li

This study identifies 39 candidate genes involved in MASLD progression using multi-omics and multi-trait analysis, validated through experimental models and an interactive web portal.

The paper identifies a UPRmt modulator, fipp-1/FIP1L1, that extends lifespan in C. elegans and is associated with metabolic homeostasis in humans.

The paper develops methods for analyzing low-depth NIPT sequencing data to accurately estimate allele frequencies and genetic effect sizes, enabling population genetic studies.

This study shows that excess fetal GDNF can prolong nephrogenesis in postnatal mouse kidneys without increasing tumor risk.

The paper introduces GeneBridge, a method for imputing gene function and predicting module connections using multi-species expression data, and demonstrates its application across 1,700 datasets.

The paper identifies evolutionarily conserved functional modules related to proteostasis in normal aging across species and links them to age-related GWAS and caloric restriction.

This study develops a chip-based sequencing method to detect monogenic diseases and chromosomal abnormalities, identifying 102 mutations in 63 patients with 69 new mutations.