Scalable expansion of human iNKT cells: single-cell profiling and in vivo control of GvHD with preserved GvL activity
Jordan Brouard, Cristina Caraiman, Ghislain Fiévet, Lucile Monchablon, Téreza Coman, Sébastien Hergalant, Simona Pagliuca, David Moulin, Marie‐Thérèse Rubio
This paper develops a scalable method to expand human CD4- iNKT cells from PBMCs using IL-15 and -GalCer, showing improved GVHD control and GVL activity in preclinical models.
bioRxiv · Sep 16, 2026 · PreprintImmunology