Nicotinamide Metabolism Reprogramming Drives Reversible Senescence of Glioblastoma Cells
Ashwin Narayanan, Mirca Saras Saurty-Seerunghen, Jessica Michieletto, Virgile Delaunay, Arnaud Bruneel, Thierry Dupré, Chris Ottolenghi, Clément Pontoizeau, Lucrezia Ciccone, Andreas De La Vara, Ahmed Idbaïh, Laurent Turchi, Thierry Virolle, Hervé Chneiweiss, Marie‐Pierre Junier, Elias A. El-Habr
This study shows nicotinamide induces reversible senescence in glioblastoma cells by reprogramming metabolism and reducing SOX2, with senescent cells retaining tumor-forming ability.
Cellular and Molecular Life Sciences · Mar 21, 2025Peer-reviewedCancer Biology