Mirca Saras Saurty-Seerunghen

This paper introduces a method for targeted sequencing of expressed mutations in single cells using RNA-templated gap filling with BstFL polymerase, enabling simultaneous transcriptomic and mutation profiling.

The paper identifies tumor-specific malignant cell types encoded across the transcriptome, independent of patient origin or computational biases.

This study shows nicotinamide induces reversible senescence in glioblastoma cells by reprogramming metabolism and reducing SOX2, with senescent cells retaining tumor-forming ability.