Elias A. El-Habr

Human cortico-vascular assembloids reveal a CELF2-AHNAK-dependent switch from neuronal to endothelial tropism in glioblastoma cells

This study develops a human cortico-endothelial assembloid model to investigate glioblastoma cell tropism, identifying CELF2 and AHNAK as key regulators of neuronal versus endothelial invasion.

A unique malignant cell type per patient tumor is encoded in each cancer cell transcriptome.

The paper identifies tumor-specific malignant cell types encoded across the transcriptome, independent of patient origin or computational biases.

Nicotinamide Metabolism Reprogramming Drives Reversible Senescence of Glioblastoma Cells

This study shows nicotinamide induces reversible senescence in glioblastoma cells by reprogramming metabolism and reducing SOX2, with senescent cells retaining tumor-forming ability.

Immune Cells Infiltration of Patient Derived Glioblastoma Cells spheroids in Acoustic Levitation in Bulk Acoustic Wave devices

The paper describes an acoustofluidic device for creating 3D tumoroids from patient-derived glioblastoma cells and shows immune cell infiltration in these tumoroids.

Oncometabolite-driven enhancer hypermethylation promotes a hyporesponsive microglial state in IDH-mutant gliomas

This study shows that oncometabolite D-2HG drives enhancer hypermethylation in IDH-mutant gliomas, leading to hyporesponsive microglia and reduced immune reactivity.