Unraveling the YAP1-TGFβ1 axis: a key driver of androgen receptor loss in prostate cancer-associated fibroblasts
Edward E. Brunner, Elisabeth Damisch, Melanie Emma Groninger, Francesco Baschieri, François Tyckaert, Lukas Nommensen, Lucy Neumann, Georgios Fotakis, Zlatko Trajanoski, Georg Schäfer, Martin Puhr, Isabel Heidegger, Michael J. Ausserlechner, Christian Ploner, Sofia Karkampouna, , Natalie Sampson
This study identifies the YAP1-TGFβ1 axis as a driver of androgen receptor loss in prostate cancer-associated fibroblasts, showing its role in promoting aggressive disease and resistance to therapy.
Journal of Experimental & Clinical Cancer Research · Dec 1, 2025Peer-reviewedCancer Biology