Author

Sofia Karkampouna

University of BernORCID 0000-0002-1716-5237Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:proteomics· 2 Assay:spatial transcriptomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Francesco BonolloiD· 4 shared Marianna Kruithof‐de JulioiD· 3 shared Adriano Luca MartinelliiD· 2 shared Andrea BrunelloiD· 2 shared Elisabeth DamischiD· 2 shared Éva CompératiD· 2 shared George Niklaus ThalmanniD· 2 shared Lukas NommenseniD· 2 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCancer Biology

Francesco BonolloORCID

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Author profile →

4 papers

Recent·Most cited

Spatial single-cell proteomics defines multicellular niches in the primary prostate cancer microenvironment

Adriano Luca Martinelli, Andrea Brunello, Melissa Ensmenger, Sofia Karkampouna, Francesco Bonollo, Éva Compérat, Andrea Lunardi, Beat Roth, Martin Spahn, George Niklaus Thalmann, Elena Brunner, Elisabeth Damisch, Lukas Nommensen, Natalie Sampson, Marianna Rapsomaniki, Marianna Kruithof‐de Julio

The paper uses spatial single-cell proteomics to map multicellular niches in primary prostate cancer, identifying prognostic cell types and niches beyond Gleason grading.

bioRxiv · May 5, 2026 · PreprintCancer Biology

Iron Metabolism as a Therapeutic Vulnerability in Stem Cell-Like Castration-Resistant Prostate Cancer

Wanli Cheng, Andrea Brunello, Francesco Bonollo, Thomas M. Marti, Panagiotis Chouvardas, David P. Labbé, Marta De Menna, George Niklaus Thalmann, Sofia Karkampouna, Marianna Kruithof‐de Julio

This study identifies iron metabolism as a therapeutic target in stem cell-like castration-resistant prostate cancer by showing that inhibiting NRF2 induces ferroptosis in CD44hi cells.

bioRxiv · Feb 25, 2026 · PreprintCancer Biology

Unraveling the YAP1-TGFβ1 axis: a key driver of androgen receptor loss in prostate cancer-associated fibroblasts

Edward E. Brunner, Elisabeth Damisch, Melanie Emma Groninger, Francesco Baschieri, François Tyckaert, Lukas Nommensen, Lucy Neumann, Georgios Fotakis, Zlatko Trajanoski, Georg Schäfer, Martin Puhr, Isabel Heidegger, Michael J. Ausserlechner, Christian Ploner, Sofia Karkampouna, , Natalie Sampson

This study identifies the YAP1-TGFβ1 axis as a driver of androgen receptor loss in prostate cancer-associated fibroblasts, showing its role in promoting aggressive disease and resistance to therapy.

Journal of Experimental & Clinical Cancer Research · Dec 1, 2025Peer-reviewedCancer Biology

Multiplexed tumor profiling with generative AI accelerates histopathology workflows and improves clinical predictions

Pushpak Pati, Sofia Karkampouna, Francesco Bonollo, Éva Compérat, Martina Radić, Martin Spahn, Adriano Luca Martinelli, Martin Wartenberg, Marianna Kruithof‐de Julio, Marianna Rapsomaniki

This paper introduces VirtualMultiplexer, a generative AI tool that translates H&E images to IHC images, improving clinical predictions and accelerating histopathology workflows.

bioRxiv · Nov 29, 2023 · PreprintBioinformatics