Amyloid precursor protein mediates deficits in corticogenesis in Down syndrome cortical organoids
Karen Rakowiecki, Deepika Patel, Luis Aponte Cofresi, Orly Lazarov
This study shows that reducing APP gene copy number in Down syndrome cortical organoids improves neural progenitor cell proliferation and neuronal differentiation.
bioRxiv · Jul 26, 2025 · PreprintNeuroscience