Author

Deepika Patel

University of Illinois ChicagoORCID 0000-0002-2976-4413Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Research Focus:clustering· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1

Frequent Co-Authors

Orly LazaroviD· 3 shared Karen Rakowiecki· 2 shared Luis Aponte Cofresi· 2 shared Aashutosh ShettiiD· 1 shared Bauke Buwalda· 1 shared Ellis Qualls· 1 shared Elvis QuiroziD· 1 shared Ioannis KoutlasiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersNeuroscience

Orly LazarovORCID

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4 papers

Recent·Most cited

NeuroscienceMedical Research ArchivesPeer-reviewedJan 1, 2026

Amyloid precursor protein dosage normalization rescues neurogenesis and Alzheimer's Disease phenotypes associated with Down Syndrome

Deepika Patel, Karen Rakowiecki, Orly Lazarov

This study investigates the role of APP overdose in Down Syndrome by reducing APP dosage in DS iPSCs and assessing its impact on neurogenesis and Alzheimer's disease pathology.

DOI 10.18103/mra.2026.0302

humanexperimental assay

𝕏 PostBluesky

NeurosciencebioRxivPreprintJul 26, 2025

Amyloid precursor protein mediates deficits in corticogenesis in Down syndrome cortical organoids

Karen Rakowiecki, Deepika Patel, Luis Aponte Cofresi, Orly Lazarov

This study shows that reducing APP gene copy number in Down syndrome cortical organoids improves neural progenitor cell proliferation and neuronal differentiation.

DOI 10.1101/2025.07.26.666926

humanspatial transcriptomics

𝕏 PostBluesky

NeurosciencebioRxivPreprintSep 23, 2023

Caveolin-1 Regulates Neurogenesis and Learning and Memory by Modulation of Mitochondrial Dynamics

Terilyn K. L. Stephen, Deepika Patel, Luis Aponte Cofresi…·Orly Lazarov

This study shows that Caveolin-1 regulates neurogenesis and learning by modulating mitochondrial dynamics in neural progenitor cells.

1 citation

mouseexperimental assay

𝕏 PostBluesky

NeurosciencebioRxivPreprintFeb 12, 2020

Single exposure to social defeat or immobilization stress fails to induce lasting alterations in general anxiety and hippocampal neurogenesis in Wistar and wild-type Groningen rats

Deepika Patel, Ioannis Koutlas, Sebastiaan H. de Waard, Bauke Buwalda

DOI 10.1101/2020.02.12.946186

ratstatistical model

𝕏 PostBluesky