Author

Karen Rakowiecki

University of Illinois Chicago

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Research Focus:clustering· 1 Research Focus:drug response / drug discovery· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Deepika PateliD· 2 shared Orly LazaroviD· 2 shared Luis Aponte Cofresi· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

3 top collaborators · 3 mutual co-author links

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2 shared papersNeuroscience

Deepika PatelORCID

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2 papers

Recent·Most cited

NeuroscienceMedical Research ArchivesPeer-reviewedJan 1, 2026

Amyloid precursor protein dosage normalization rescues neurogenesis and Alzheimer's Disease phenotypes associated with Down Syndrome

Deepika Patel, Karen Rakowiecki, Orly Lazarov

This study investigates the role of APP overdose in Down Syndrome by reducing APP dosage in DS iPSCs and assessing its impact on neurogenesis and Alzheimer's disease pathology.

DOI 10.18103/mra.2026.0302

humanexperimental assay

𝕏 PostBluesky

NeurosciencebioRxivPreprintJul 26, 2025

Amyloid precursor protein mediates deficits in corticogenesis in Down syndrome cortical organoids

Karen Rakowiecki, Deepika Patel, Luis Aponte Cofresi, Orly Lazarov

This study shows that reducing APP gene copy number in Down syndrome cortical organoids improves neural progenitor cell proliferation and neuronal differentiation.

DOI 10.1101/2025.07.26.666926

humanspatial transcriptomics

𝕏 PostBluesky