Closing the loop: Teaching single-cell foundation models to learn from perturbations
Yash Pershad, Tarak Nandi, Joseph C. Van Amburg, Alyssa Parker, Luiza Ostrowski, Hannah K. Giannini, David E. Ong, Jonathan Brett Heimlich, Esther A. Obeng, Katrin Rhodes Ericson, Anupriya Agarwal, Ravi Madduri, Alexander G. Bick
The paper introduces a closed-loop framework for single-cell foundation models that incorporates perturbation data to improve prediction accuracy, identifying therapeutic targets and pathways in RUNX1-familial platelet disorder.
bioRxiv · Jul 8, 2025 · PreprintBioinformatics