BioinformaticsbioRxivPreprint
Closing the loop: Teaching single-cell foundation models to learn from perturbations
Yash Pershad, Tarak Nandi, Joseph C. Van Amburg…·Alexander G. Bick
The paper introduces a closed-loop framework for single-cell foundation models that incorporates perturbation data to improve prediction accuracy, identifying therapeutic targets and pathways in RUNX1-familial platelet disorder.