SAM-AMP lyases in CRISPR defence and anti-defence
Haotian Chi, Stephen McMahon, Lukas Daniel-Pedersen, Shirley Graham, T.M. Gloster, Malcolm F. White
This study investigates the structure and function of a SAM-AMP lyase from Clostridium botulinum, showing its ability to substitute for a phosphodiesterase in providing anti-phage defence.
bioRxiv · Apr 28, 2025 · PreprintBiochemistry