Author

Stephen McMahon

University of St Andrews

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Approach:biophysical modeling· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

Haotian ChiiD· 2 shared Malcolm F. WhiteiD· 2 shared T.M. GlosteriD· 2 shared Lukas Daniel-Pedersen· 1 shared Marta Orzechowski· 1 shared Shirley GrahamiD· 1 shared Ville HoikkalaiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 17 mutual co-author links

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2 shared papersBiochemistry

Haotian ChiORCID

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2 papers

Recent·Most cited

A viral SAVED protein with ring nuclease activity degrades the CRISPR second messenger cA4

Marta Orzechowski, Ville Hoikkala, Haotian Chi, Stephen McMahon, T.M. Gloster, Malcolm F. White

The paper shows that a viral SAVED domain, AcrIII-2, degrades the CRISPR second messenger cA4, inhibiting its effectors.

Biochemical Journal · Nov 1, 2025Peer-reviewedBiochemistry

SAM-AMP lyases in CRISPR defence and anti-defence

Haotian Chi, Stephen McMahon, Lukas Daniel-Pedersen, Shirley Graham, T.M. Gloster, Malcolm F. White

This study investigates the structure and function of a SAM-AMP lyase from Clostridium botulinum, showing its ability to substitute for a phosphodiesterase in providing anti-phage defence.

bioRxiv · Apr 28, 2025 · PreprintBiochemistry