Author
University of St AndrewsORCID 0009-0007-4421-5598Unclaimed ORCID profile · follow to get notified of new preprints
7 papers
Recent·Most cited
Haotian Chi, Stephen A. McMahon, Shirley Graham, Malcolm F. White
This study investigates the structural and biochemical properties of Csx15, a ring nuclease that binds cyclic nucleotides and regulates antiviral defense by modulating cOA levels.
Haotian Chi, Ville Hoikkala, Stephen A. McMahon…·Malcolm F. White
This study describes the structure and mechanism of Crn4, a ring nuclease that degrades cyclic oligoadenylates and modulates type III CRISPR immunity.
Marta Orzechowski, Ville Hoikkala, Haotian Chi…·Malcolm F. White
The paper shows that a viral SAVED domain, AcrIII-2, degrades the CRISPR second messenger cA4, inhibiting its effectors.
Ville Hoikkala, Haotian Chi, Sabine Grüschow…·Malcolm F. White
The paper analyzes type III CRISPR-Cas loci across 38,742 prokaryotic genomes to identify and characterize ring nucleases that regulate cyclic oligoadenylate levels.
Haotian Chi, Stephen McMahon, Lukas Daniel-Pedersen…·Malcolm F. White
This study investigates the structure and function of a SAM-AMP lyase from Clostridium botulinum, showing its ability to substitute for a phosphodiesterase in providing anti-phage defence.
This study investigates the role of NYN, a ribonuclease in the Bacteroides fragilis type III CRISPR system, showing it cleaves ssRNA in a Mn2+-dependent manner, likely involved in crRNA maturation for antiviral defence.
Haotian Chi, Ville Hoikkala, Sabine Grüschow…·Malcolm F. White
This study identifies SAM-AMP as a novel second messenger in type III-B CRISPR systems, used for antiviral signaling by conjugating ATP to S-adenosyl methionine.