Shirley Graham

The paper defines the mechanism of the MANTIS defence system in Pseudomonas aeruginosa, showing how dual ATPases couple self-modification to non-self restriction through adenine hemimethylation and cleavage.

This study investigates the structural and biochemical properties of Csx15, a ring nuclease that binds cyclic nucleotides and regulates antiviral defense by modulating cOA levels.

The paper shows the type II Panoptes system generates cyclic tri-adenylate (cA3) to keep a CARF-TM effector inactive, and its degradation leads to membrane permeabilization and growth arrest.

This study describes the structure and mechanism of Crn4, a ring nuclease that degrades cyclic oligoadenylates and modulates type III CRISPR immunity.

The paper analyzes type III CRISPR-Cas loci across 38,742 prokaryotic genomes to identify and characterize ring nucleases that regulate cyclic oligoadenylate levels.

This study investigates the structure and function of a SAM-AMP lyase from Clostridium botulinum, showing its ability to substitute for a phosphodiesterase in providing anti-phage defence.