First gene-edited calf with reduced susceptibility to a major viral pathogen
Aspen M. Workman, Michael P. Heaton, Brian L. Vander Ley, Dennis A. Webster, Luke Sherry, Jonathan R. Bostrom, Sabreena A. Larson, Ted Kalbfleisch, Gregory P. Harhay, Erin E. Jobman, Daniel F. Carlson, Tad Stewart Sonstegard
The paper describes the creation of a gene-edited calf with reduced susceptibility to BVDV through CD46 modification, showing no adverse effects and confirming the effectiveness of the approach.
PNAS Nexus · May 1, 2023Peer-reviewedGenomics