Daniel F. Carlson

This paper develops a swine reporter model to evaluate gene delivery vectors in a large animal system and demonstrates its utility for assessing biodistribution, safety, and administration methods.

The paper describes the creation of a gene-edited calf with reduced susceptibility to BVDV through CD46 modification, showing no adverse effects and confirming the effectiveness of the approach.

GeneWeld enables efficient and precise targeted integration in multiple species using CRISPR/Cas9 with minimal homology arms.