CRISPRa screening with real world evidence identifies potassium channels as neuronal entry factors and druggable targets for SARS-CoV-2
Chengkun Wang, Ravi K. Dinesh, Yuanhao Qu, Arjun Rustagi, Henry C. Cousins, James R. Zengel, Tianyi Zhang, Nicholas Magazine, Yinglong Guo, Taryn O. Hall, Aimee Beck, Lucas Miecho Heilbroner, Grace Peters-Schulze, Aaron J. Wilk, Luke Tso, , Le Cong
The paper uses CRISPRa screening and real-world data to identify KCNA6 as a neuronal entry factor for SARS-CoV-2 and shows dalfampridine can suppress viral entry.
bioRxiv · Jul 1, 2021 · PreprintGenomics