Multivalent designed proteins protect against SARS-CoV-2 variants of concern
Andrew C. Hunt, James Brett Case, Young‐Jun Park, Longxing Cao, Kejia Wu, Alexandra C. Walls, Zhuoming Liu, John E. Bowen, Andy Hsien-Wei Yeh, Shally Saini, Louisa Helms, Yan Ting Zhao, Tien-Ying Hsiang, Tyler N. Starr, Inna Goreshnik, , David A. Baker
The paper designs and characterizes trivalent miniprotein binders that neutralize SARS-CoV-2 variants with low pM IC50 values and provide prophylactic and therapeutic protection in mice.
Science Translational Medicine · Apr 12, 2022Peer-reviewedSynthetic Biology