LIN28B is a post-transcriptional regulator of Wnt signalling in myeloid leukemia cells and dual targeting promotes cytotoxicity
Okan Sevim, Megan Wagstaff, Rebecca E. Ling, Aaron Goff, David A. Palmer, H. Park, Katharine Hills, Leandro Castellano, Sarah Faith Newbury, Anindita Roy, M Hartmann, Gareth Morgan
This study identifies LIN28B as a post-transcriptional regulator of Wnt/{beta}-catenin signalling in myeloid leukemia cells and shows that dual targeting enhances cytotoxicity.
bioRxiv · Oct 19, 2026 · PreprintCancer Biology