Author

A Goff

University of SussexORCID 0000-0002-5356-9298Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Assay:metagenomics· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

David A. PalmeriD· 2 shared Gareth MorganiD· 2 shared H. ParkiD· 2 shared Megan WagstaffiD· 2 shared Okan SevimiD· 2 shared Sarah Faith NewburyiD· 2 shared Allison BlairiD· 1 shared Anindita RoyiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersCancer Biology

David A. PalmerORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

LIN28B is a post-transcriptional regulator of Wnt signalling in myeloid leukemia cells and dual targeting promotes cytotoxicity

Okan Sevim, Megan Wagstaff, Rebecca E. Ling, Aaron Goff, David A. Palmer, H. Park, Katharine Hills, Leandro Castellano, Sarah Faith Newbury, Anindita Roy, M Hartmann, Gareth Morgan

This study identifies LIN28B as a post-transcriptional regulator of Wnt/{beta}-catenin signalling in myeloid leukemia cells and shows that dual targeting enhances cytotoxicity.

bioRxiv · Oct 19, 2026 · PreprintCancer Biology

TOE1 influences canonical Wnt signalling in myeloid leukaemia cells through LEF-1 modulation and regulates the proliferation of haematopoietic cells through PAK2.

H. Park, O Sevim, M Wagstaff, A Goff, D Palmer, B Kim, K Heesom, Allison Blair, S Newbury, Ethan L. Morgan, BP Towler, Timothy J. T. Chevassut, RG Morgan

This study identifies TOE1 as a novel β-catenin interactor in myeloid cells that modulates Wnt signaling via LEF-1 and regulates proliferation through PAK2.

bioRxiv · Dec 15, 2025 · PreprintCancer Biology