Sarah Faith Newbury

LIN28B is a post-transcriptional regulator of Wnt signalling in myeloid leukemia cells and dual targeting promotes cytotoxicity

This study identifies LIN28B as a post-transcriptional regulator of Wnt/{beta}-catenin signalling in myeloid leukemia cells and shows that dual targeting enhances cytotoxicity.

TOE1 influences canonical Wnt signalling in myeloid leukaemia cells through LEF-1 modulation and regulates the proliferation of haematopoietic cells through PAK2.

This study identifies TOE1 as a novel β-catenin interactor in myeloid cells that modulates Wnt signaling via LEF-1 and regulates proliferation through PAK2.

Characterisation of the in-vivo miRNA landscape in Drosophila ribonuclease mutants reveals Pacman mediated regulation of the highly conserved let-7 cluster during apoptotic processes

The paper characterizes miRNA expression in Drosophila wing imaginal discs and shows Pacman regulates the let-7 cluster, affecting apoptosis.

Genome-wide analyses of XRN1-sensitive targets in osteosarcoma cells identifies disease-relevant transcripts containing G-rich motifs.

The paper identifies XRN1-sensitive transcripts in osteosarcoma cells and shows they contain G-rich motifs, suggesting XRN1 regulates lncRNAs involved in disease progression.

Dis3L2 regulates cellular proliferation through a PI3-Kinase dependent signalling pathway

This study identifies Dis3L2 as a regulator of cell proliferation through a PI3-Kinase dependent pathway in both Drosophila and human cells.