Improving efficiency of homology-directed repair with ZIP CRISPR
Chloé Thibault, Juliette Rosier, R Espasa, V Marin, M Riandière, Camille Bergès, S Fayet, Isabelle Lamrissi‐Garcia, M Lalanne, Thomas Trian, S. Bui, Sandrine Dabernat, Julian Boutin, François Moreau‐Gaudry, Aurélie Bedel
ZIP CRISPR improves homology-directed repair efficiency by delivering ssODN templates via a heteroduplex gRNA-ssODN system, achieving up to 12-fold higher HDR editing in multiple cell types.
bioRxiv · Mar 13, 2025 · PreprintBioengineering