Author

Thomas Trian

InsermORCID 0000-0002-2567-4867Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Microbiology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Patrick BergeriD· 2 shared Anastasiia V. TymchenkoiD· 1 shared Aurélie BedeliD· 1 shared Benoı̂t Roger· 1 shared Camille BergèsiD· 1 shared Chloé ThibaultiD· 1 shared Elise Maurat· 1 shared Fabien BeaufilsiD· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersMicrobiology

Patrick BergerORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A distinct signature of interferon-stimulated genes linked to cross-protection against secondary viral infections in primary bronchial epithelial cells

Anastasiia V. Tymchenko, Morgane Fierville, Pauline Estèves, Pierre Gourdan, Sophie Germain, Rihab Ben-Sghaier, Muriel Faure, Benoı̂t Roger, Fabienne Rayne, Nicolas Landrein, Virginie Magnone, Pascal Barbry, Patrick Berger, Fabien Beaufils, Laure‐Emmanuelle Zaragosi, , Thomas Trian

bioRxiv · Jul 1, 2026 · PreprintMicrobiology

Improving efficiency of homology-directed repair with ZIP CRISPR

Chloé Thibault, Juliette Rosier, R Espasa, V Marin, M Riandière, Camille Bergès, S Fayet, Isabelle Lamrissi‐Garcia, M Lalanne, Thomas Trian, S. Bui, Sandrine Dabernat, Julian Boutin, François Moreau‐Gaudry, Aurélie Bedel

ZIP CRISPR improves homology-directed repair efficiency by delivering ssODN templates via a heteroduplex gRNA-ssODN system, achieving up to 12-fold higher HDR editing in multiple cell types.

bioRxiv · Mar 13, 2025 · PreprintBioengineering

Fibrocyte accumulation in bronchi: a cellular hallmark of COPD

Isabelle Dupin, Matthieu Thumerel, Elise Maurat, Florence Coste, Hugues Begueret, Thomas Trian, Michel Montaudon, Roger Marthan, Pierre-Olivier Girodet, Patrick Berger

This study quantifies fibrocyte density in bronchial tissue of COPD patients and controls, finding increased fibrocytes associated with reduced lung function and increased bronchial wall thickness.

bioRxiv · Oct 23, 2018 · PreprintPhysiology